Thursday, August 21, 2008

From Williams haematology 7th Edition


I. Primary lymphocytosis

A. Lymphocytic malignancies

1. Acute lymphocytic leukemia (Chap. 91)

2. Chronic lymphocytic leukemia and related disorders (Chap. 92)

3. Prolymphocytic leukemia (Chap. 92)

4. Hairy cell leukemia133 (Chap. 93)

5. Adult T cell leukemia (Chaps. 92 and 96)

6. Lymphoma cell leukemia134 (Chap. 96)

7. Large granular lymphocytic leukemia135 (Chap. 94)

a. NK cell leukemia136 (Chap. 94)

b. CD8+ T cell large granular lymphocytic leukemia137,138,139

c. CD4+ T cell large granular lymphocytic leukemia53,140

d. / T cell large granular lymphocytic leukemia141

B. Essential monoclonal B cell lymphocytosis6 (Chap. 92)

C. Persistent polyclonal B cell lymphocytosis9,10

II. Reactive lymphocytosis

A. Mononucleosis syndromes (Chap. 84)

1. Epstein-Barr virus38,142,143,144,145,146

2. Cytomegalovirus41,42,147,148,149,150,151,152

3. Human immunodeficiency virus153,154,155,156,157,158

4. Herpes simplex virus type II

5. Rubella virus

6. Toxoplasma gondii159

7. Adenovirus

8. Infectious hepatitis virus

9. Dengue fever virus160,161,162

10. Human herpes virus type 6 (HHV-6)77,163

11. Human herpes virus type 8 (HHV-8)164

12. Varicella zoster virus165

B. Bordetella pertussis45

C. NK cell lymphocytosis54,55,56,73,75,166,167,168,169

D. Stress lymphocytosis (acute)69

1. Cardiovascular collapse66

a. Acute cardiac failure

b. Myocardial infarction

2. Staphylococcal toxic shock syndrome170

3. Drug-induced68,77,171

4. Major surgery

5. Sickle cell crisis172

6. Status epilepticus

7. Trauma65,66

E. Hypersensitivity reactions

1. Insect bites73,74,75

2. Drugs76,78,80,81,173

F. Persistent lymphocytosis (subacute or chronic)

1. Cancer84

2. Cigarette smoking15,174

3. Hyposplenism86

4. Chronic infection

a. Leishmaniasis175

b. Leprosy176

c. Strongyloidiasis58,59,60

5. Thymoma83

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